Chelsea head to London Stadium for their second Premier League fixture, looking to respond after a frustrating goalless draw with Crystal Palace in their opener.
Both sides come into this derby still searching for a first win of the campaign, and the pressure to claim early points is already rising.
Robert Sanchez is expected to remain in goal, having kept a clean sheet last weekend. In defence, Tosin Adarabioyo is set to return after missing the Palace clash with a minor knock, likely stepping in for Josh Acheampong alongside Trevoh Chalobah.
Marc Cucurella and Reece James should continue as full-backs on the left and right.
Midfield looks settled. Enzo Fernandez and Moises Caicedo are tipped to hold the double pivot again, with Romeo Lavia not yet ready to return from injury.
Cole Palmer is likely to retain the No. 10 role, tasked with sparking creativity against a compact West Ham side.
On the flanks, Jamie Gittens is expected to start on the left despite a subdued display last time out, while Pedro Neto could line up on the right, looking to bring directness and width.
Up front, Joao Pedro will hope to open his Premier League account in blue, having led the line without scoring in the opener.
Liam Delap remains an option from the bench but is unlikely to displace the Brazilian for this clash.
Chelsea’s performance against the Hammers will be under close watch, not just for the result, but for signs of cohesion as the squad seeks early rhythm under pressure.