Manchester United travel to the Doosan Arena to face Viktoria Plzen in the Europa League group stage tonight, with kick-off scheduled for 5.45pm UK time.
The Red Devils sit 12th in the group standings with nine points from their opening five matches, making victory essential if they are to push for an automatic qualification berth.
Ruben Amorim is demanding a reaction from his squad following the disappointing 3-2 loss at home to Nottingham Forest over the weekend. The United boss has shuffled his pack, but Andre Onana keeps his place in goal.
Lisandro Martinez and Matthijs de Ligt continue in the backline, while Noussair Mazraoui replaces Leny Yoro to complete the defensive trio. Tyrell Malacia and Diogo Dalot operate in the wing-back roles. In midfield, Casemiro returns to partner Bruno Fernandes, with Kobbie Mainoo and Manuel Ugarte dropping to the bench.
In attack, Amad Diallo is deployed higher up the pitch, with Marcus Rashford recalled to take the place of Alejandro Garnacho. Joshua Zirkzee leads the front line, with Rasmus Hojlund among the substitutes.
Confirmed Line-ups:
Viktoria Plzen: Jedlička, Cadu, Dweh, Marković, Jemelka, Souaré, Červ, Kalvach, Vydra, Šulc, Vašulín.
Subs: Tvrdon, Baier, Hejda, Paluska, Kopic, Sojka, Mosquera, Panos, Havel, Sloncik, Jirka, Adu.
Manchester United: Onana, Mazraoui, De Ligt, Martinez, Malacia, Dalot, Casemiro, Fernandes, Amad, Rashford, Zirkzee.
Subs: Bayindir, Lindelof, Maguire, Yoro, Collyer, Eriksen, Mainoo, Mount, Ugarte, Antony, Garnacho, Hojlund.